Median daily dose g/kg/d

(Range)

Entire treatment

Dose until documented OR achieved

Dose until documented SD achieved

Treated patients

N

A10

AS2-1

A10

AS2-1

A10

AS2-1

All

41

8.74

(0.48 - 24.58)

0.35

(0.13 - 0.51)

10.58

(9.46 - 16.89)

0.35

(0.32 - 0.44)

9.23

(6.75 - 24.58)

0.39

(0.27 - 0.47)

DIPG

12

10.26 (1.85 - 24.58)

0.37 (0.27 - 0.51)

11.46 (9.46 - 16.89)

0.40 (0.34 - 0.44)

8.65 (6.75 - 24.58)

0.41 (0.27 - 0.47)

AA

8

6.29 (1.93 - 13.09)

0.30 (0.22 - 0.44)

9.87^*

0.32^*

7.88^*

0.29^*

GBM

12

8.47 (1.61 - 13.38)

0.33 (0.13 - 0.46)

_

_

12.04 (10.72 - 13.36)

0.40 (0.39 - 0.40)